Bioequivalence and Bioavailability Forum

Sequence effect Vs Subject effect? [Study Assessment]

posted by mittyri – Russia, 2019-07-28 17:19 (1727 d 20:34 ago) – Posting: # 20457
Views: 5,789

Hi Helmut,

❝ Since we are in the same boat and out of curiosity: p-values of the sequence effect were given by the CRO and also by the BfArM with 0.0077 (AUC) and 0.0252 (C_max).

❝ Recalculated in Phoenix WinNonlin 8.1 and R 3.6.1 (function lm() of stats):

❝

PK metric p (period) p (sequence)


❝   AUC        0.0321      2.42·10^–5

❝   Cmax       0.0358      2.36·10^–5

What‽

which one sequence effect are you referring to?

—
Kind regards,
Mittyri

Complete thread:

Good News, Bad News Datacollector 2019-07-27 12:09 [Study Assessment]
- Good News only Helmut 2019-07-27 13:15
  - Good News only, but not according to some Datacollector 2019-07-27 13:34
    - ’Some’ should read the GL (and again, and again) Helmut 2019-07-27 13:48
    - Good News only, but not according to some ElMaestro 2019-07-27 13:50
      - My stuff Helmut 2019-07-27 16:55
        
        My stuff ElMaestro 2019-07-27 17:38
        
        My stuff Datacollector 2019-07-27 19:13
        
        ≡ Helmut 2019-07-27 23:53
        
        Sequence effect Vs Subject effect?mittyri 2019-07-28 15:19
        
        Sequence effect Vs Subject effect? Helmut 2019-07-28 15:59
        
        Sequence effect Vs Subject effect? mittyri 2019-07-28 16:20
        
        Oops! Helmut 2019-07-28 16:36

Sequence effect Vs Subject effect? [Study As­sess­ment]

Complete thread:

Sequence effect Vs Subject effect? [Study Assessment]