Biorelevant Dissolution - FeSSGF with Ensure Plus [Dissolution / BCS / IVIVC]

posted by thalita_m  – Brazil, 2019-07-26 13:55  – Posting: # 20445
Views: 758

Hello everyone,

I am doing work with biorelevant dissolution media and the literature indicates the use of dietary supplements like Ensure Plus (Abott) to simulate the gastric fed medium (FeSSGF).
Has anyone around here ever done dissolution trials with this supplement? Any tips for drug recovery / extraction?

We tested using acetonitrile for extraction, the tests with the raw material showed a good recovery of the drug, but when we did the dissolution test, the drug only appeared after 30 minutes. We still do not know if it was a matter of homogenization or if the formulation did not disintegrate.

Thanks in advance.

Complete thread:

Activity
 Admin contact
20,648 posts in 4,328 threads, 1,436 registered users;
online 28 (0 registered, 28 guests [including 21 identified bots]).
Forum time: 03:42 UTC (Europe/Vienna)

Freedom is always and exclusively
freedom for the one
who thinks differently.    Rosa Luxemburg

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5