A lie is a lie is a lie ... [🇷 for BE/BA]

posted by d_labes  – Berlin, Germany, 2019-04-25 21:59 (1821 d 14:08 ago) – Posting: # 20236
Views: 12,150

Dear All,
especially the contributors to this thread.

I have a simple opinion about that mean PK profile graphs:
Whatever sophisticated group statistics underlying such mean profile you choose, whatever sophistic rules regarding missings and / or values below LLOQ, whatever sophistic graphical effects
you choose - you end with a statistical lie.
A lie
is a lie
is a lie ...

Thus my recommendation: Don't invest too many Gehirnschmalz (brain power).
Try to go without them.
And since that unfortunately doesn't function in many cases, as I know of course, choose a simple effortless solution and go with that. The Blume/Mutschler graphs shown in Helmuts post point in the correct direction.
I only had some seldom requests from some smart alecs to change the graphs. If this happens it is early enough to invest some grey matter.
—
Regards,

Detlew

Complete thread:

UA Flag
Activity
 Admin contact
22,988 posts in 4,825 threads, 1,658 registered users;
116 visitors (0 registered, 116 guests [including 6 identified bots]).
Forum time: 12:07 CEST (Europe/Vienna)

The whole purpose of education is
to turn mirrors into windows.    Sydney J. Harris

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5