Graphing Mean PK profile [R for BE/BA]

posted by nobody – 2019-04-24 14:15  – Posting: # 20226
Views: 3,412

» Some people set all BQLs to zero in order to calculate the arithmetic mean. Others set the first BQL after tmax to LLOQ/2, and, and, and… There will always be a bias.

How would you otherwise calculate the geo. mean profile?

And AUCtlast is a mess with different tlast for T and R and and and. Statistics is always some kind of abstraction. Do a spaghetti plot for T and R and individual T+R for each subject and you might get completely different "ideas" / insights...

Kindest regards, nobody

Complete thread:

Activity
 Admin contact
20,255 posts in 4,263 threads, 1,398 registered users;
online 13 (0 registered, 13 guests [including 9 identified bots]).
Forum time (Europe/Vienna): 08:56 CET

You should treat as many patients as possible with the new drugs
while they still have the power to heal.    Armand Trousseau

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5