Metrics for absorption [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2019-04-16 17:01  – Posting: # 20176
Views: 2,172

Hi nobody,

method of residuals, feathering, Wagner-Nelson? Smells of modeling which is not acceptable in BE. BTW, lag-times are the killer. Good luck!1,2


  1. Nerella NG, Block NH, Noonan PK. The Impact of Lag Time on the Estimation of Pharmacokinetic Parameters. I. One Compartment Model. Pharm Res. 1993;10(7):1031–6.
  2. Csizmadia F, Endrényi L. Model-Independent Estimation of Lag Times with First-Order Absorption and Disposition. J Pharm Sci. 1998;87(5):608–12. doi:10.1021/js9703333

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
20,036 posts in 4,233 threads, 1,378 registered users;
online 13 (3 registered, 10 guests [including 6 identified bots]).
Forum time (Europe/Vienna): 13:49 CET

Maturity is the capacity to endure uncertainty.    John Finley

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5