Metrics for absorption [NCA / SHAM]

posted by nobody – 2019-04-15 12:15 (756 d 20:04 ago) – Posting: # 20164
Views: 5,104

Hi

first thought

"Cmax is ...is nonspecific to it (reflects also the extent of absorption as well as the rates of disposition processes),..."

Hmm, how is AUCp not reflecting disposition processes?

"...lacks kinetic sensitivity even following a single administration."

How much sensitivity is needed in the first place? Or are we creating problems by "overly sensitive" methods with no relevance in clinical practice?

Kindest regards, nobody

Complete thread:

Activity
 Admin contact
21,446 posts in 4,483 threads, 1,511 registered users;
online 20 (0 registered, 20 guests [including 8 identified bots]).
Forum time: Tuesday 08:20 CEST (Europe/Vienna)

The fact that some geniuses were laughed at
does not imply that all who are laughed at are geniuses.    Carl Sagan

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5