Metrics for absorption [NCA / SHAM]

posted by nobody – 2019-04-15 12:15  – Posting: # 20164
Views: 2,617

Hi

first thought

"Cmax is ...is nonspecific to it (reflects also the extent of absorption as well as the rates of disposition processes),..."

Hmm, how is AUCp not reflecting disposition processes?

"...lacks kinetic sensitivity even following a single administration."

How much sensitivity is needed in the first place? Or are we creating problems by "overly sensitive" methods with no relevance in clinical practice?

Kindest regards, nobody

Complete thread:

Activity
 Admin contact
20,242 posts in 4,259 threads, 1,397 registered users;
online 6 (0 registered, 6 guests [including 4 identified bots]).
Forum time (Europe/Vienna): 03:36 CET

Operational hectic replaces
intellectual calms.    Alexander Huiskes

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5