Bioequivalence and Bioavailability Forum • old, obvious?

old, obvious? [Bioanalytics]

posted by ElMaestro – Denmark, 2019-03-19 09:26 (1863 d 11:20 ago) – Posting: # 20049
Views: 5,029

Hi Hötzi,

❝ Congratulations for an obvious solution (aka, re-inventing the wheel). ;-) See what Ohlbe wrote here and there.

Is the proposal really old and is it really obvious?

I see there was in the past a proposal or two about 1/(Conc^z) where z is not an integer, but I am not sure if there was ever anyone who:

Defined an objective function which seeks to minimize a relevant measure of departure from predictability (that same predictability which maps into the criteria of guidelines).
Showed the existence of a minimum of that function.

Novelty here is not the existence of a funky value of z, but the way of finding it, the nature of it.

—
Pass or fail!
ElMaestro

Complete thread:

Handling BLOQ values (Fisher Info etc.) mittyri 2019-03-16 14:41
- Handling BLOQ values (Fisher Info etc.) Helmut 2019-03-16 15:39
  - The smartest solution ElMaestro 2019-03-16 22:35
    - An old solution Helmut 2019-03-16 23:05
      - old, obvious?ElMaestro 2019-03-19 08:26
    - Example Helmut 2019-03-17 01:56
  - ADA example mittyri 2019-03-18 22:20
    - My beloved Ada Helmut 2019-03-19 01:34
- Handling BLOQ values (Fisher Info etc.) Ohlbe 2019-03-17 14:32
  - Handling BLOQ values (Fisher Info etc.) nobody 2019-03-18 08:14
    - Don’t weight by 1/s² Helmut 2019-03-18 11:19