Bioequivalence and Bioavailability Forum

PowerTOST: CVfromCI -> CI.BE [Study As­sess­ment]

posted by d_labes  – Berlin, Germany, 2019-02-20 15:12 (1890 d 14:03 ago) – Posting: # 19938
Views: 10,210

Dear Helmut,

❝ ...

❝ How to discover which method was used?

❝ Work backwards, i.e., see with which CV you can reproduce the reported results for each comparison.

❝ res.1 <- CI.BE(pe=pe, CV=CV.1, n=n, design=des)


❝ res.2 <- CI.BE(pe=pe, CV=CV.2, n=n, design=eval)


❝ cat(paste0("\nBack-calculated 90% CI by",


❝     "\n  Pooled ANOVA           : ",
❝     sprintf("%.2f%%%s", 100*res.1[["lower"]], "\u2013"),
❝     sprintf("%.2f%%", 100*res.1[["upper"]]),
❝     "\n  Two-at-a-Time Principle: ",
❝     sprintf("%.2f%%%s", 100*res.2[["lower"]], "\u2013"),
❝     sprintf("%.2f%%", 100*res.2[["upper"]]), "\n"))

❝

❝ Back-calculated 90% CI by

❝   Pooled ANOVA           : 85.00%–106.18%
❝   Two-at-a-Time Principle: 85.00%–106.18%

IMHO this suggestion is an orouboros.
Calculating the CV from the CI and using this CV to calculate the CI will give you always the CI used in the starting step. Regardless of the design used in both steps.
As you has demonstrated with your calculations .

Complete thread:

• CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 12:31 
  • CV values in BE studies: intra, or inter, or total? jag009 2018-01-20 19:18
    • CV values in BE studies: intra, or inter, or total? Elena777 2018-01-20 21:10
      • CV values in BE studies: intra, or inter, or total? jag009 2018-01-21 03:17
        • CV values in BE studies: intra, or inter, or total? Elena777 2018-01-21 08:21
  • CV values in BE studies: intra, or inter, or total? Helmut 2018-01-21 17:33
  • CV values in BE studies: intra, or inter, or total? ElMaestro 2018-01-21 18:17
    • CV values in BE studies: intra, or inter, or total? Elena777 2018-01-27 09:57
      • CV values in BE studies: intra, or inter, or total? Louis52 2018-02-07 20:22
        • CV values in BE studies: intra, or inter, or total? Helmut 2018-02-07 20:31
          • CV values in BE studies: intra, or inter, or total? Rosy 2019-02-19 18:33
            • PowerTOST: CVfromCI Helmut 2019-02-20 13:00
              • PowerTOST: CVfromCI -> CI.BEd_labes 2019-02-20 14:12
                • Oops! Helmut 2019-02-20 15:32
                  • Oops! df? d_labes 2019-02-20 19:45
                    • Oops! df? Helmut 2019-02-20 20:43
                      • Oops! df! d_labes 2019-02-21 10:54
                      • Oops! df? zizou 2019-02-21 11:33
                        • Oops! df? nobody 2019-02-21 12:42
                        • All the answers are here d_labes 2019-02-21 14:49
              • PowerTOST: CVfromCI Rosy 2019-02-20 15:25
                • type known.designs() in PowerTOST Helmut 2019-02-20 16:14
                  • type known.designs() in PowerTOST Rosy 2019-02-20 17:14