## inter- vs extra- [NCA / SHAM]

Dear Helmut!

Thanks a lot for the clarification! The more I get answers the more I have questions... Why do algorithms for inter- and extrapolation differ?

Let's say that the last point is NA. Then PHX will calculate it via estimated λ

» Gotcha! By specifying the linear trapezoidal you tell PHX that you

Then why does it use lambda and log elimination for unknown samples and local slope and linear elimination for known samples? What's wrong with calculation by λ

Of course I can try to think about it as a compromis (see this post), but then how to define my own rule to be sure that it is correct?

» Duno. I always describe

That's a perfect position. But sometimes we have to work with what someone has planned before.

I was always wondering how far one can go in stating his favourite methods in SOPs and SAPs? Can I write that after the calculation a statistician should have a cup of tea?

Thanks a lot for the clarification! The more I get answers the more I have questions... Why do algorithms for inter- and extrapolation differ?

Let's say that the last point is NA. Then PHX will calculate it via estimated λ

_{z}suspecting log elimination not depending from the actual AUC calculation method.» Gotcha! By specifying the linear trapezoidal you tell PHX that you

*believe*that the drug between time points is eliminated in zero (!) orderThen why does it use lambda and log elimination for unknown samples and local slope and linear elimination for known samples? What's wrong with calculation by λ

_{z}for the both cases?Of course I can try to think about it as a compromis (see this post), but then how to define my own rule to be sure that it is correct?

» Duno. I always describe

*exactly*what I plan to do in the protocol.That's a perfect position. But sometimes we have to work with what someone has planned before.

I was always wondering how far one can go in stating his favourite methods in SOPs and SAPs? Can I write that after the calculation a statistician should have a cup of tea?

—

"Being in minority, even a minority of one, did not make you mad"

"Being in minority, even a minority of one, did not make you mad"

### Complete thread:

- AUC0-tau at steady state BNR 2016-03-31 22:46
- AUC0-tau at steady state jag009 2016-03-31 23:05
- AUC0-tau at steady state BNR 2016-03-31 23:43
- RTFM Helmut 2016-04-01 00:59
- RTFM BNR 2016-04-01 02:05
- AUC0-τ estimation with time deviations Astea 2019-02-10 16:38
- AUC0-τ estimation with time deviations Helmut 2019-02-10 19:32
- Cτ for lin and lin-up/log-down Astea 2019-02-10 20:50
- Cτ by lin-/lin, lin-up/log-down, and λz Helmut 2019-02-11 01:45
- inter- vs extra-Astea 2019-02-11 19:46
- inter- vs extra- Helmut 2019-02-12 02:20
- No rule fits all mittyri 2019-02-14 12:55
- one size fits all vs goal posts Astea 2019-02-16 08:33
- one size fits all vs goal posts ElMaestro 2019-02-16 13:33
- Bias etc. Helmut 2019-02-16 14:26

- software: NCA not validated Helmut 2019-02-16 13:59
- no way out for NCA validation? mittyri 2019-02-20 21:22

- Default rules mittyri 2019-02-20 21:40

- one size fits all vs goal posts ElMaestro 2019-02-16 13:33

- one size fits all vs goal posts Astea 2019-02-16 08:33

- inter- vs extra-Astea 2019-02-11 19:46

- Cτ by lin-/lin, lin-up/log-down, and λz Helmut 2019-02-11 01:45

- Cτ for lin and lin-up/log-down Astea 2019-02-10 20:50

- AUC0-τ estimation with time deviations Helmut 2019-02-10 19:32

- RTFM Helmut 2016-04-01 00:59

- AUC0-tau at steady state BNR 2016-03-31 23:43

- AUC0-tau at steady state jag009 2016-03-31 23:05