blackwhite [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2019-02-04 15:34 (600 d 18:01 ago) – Posting: # 19862
Views: 4,079

Hi Nastia,

» […] By def Ctrough occurs at the end of dosing interval... I give up... It is impossible to distinguish!

Look up trough in an English dictionary. A kind of minimum, right? The minimum (hence in the textbooks “Cmin”) can occur anywhere in the profile. If you have no lag-time the chance to observe it at the beginning and the end is 50% each (by definition).
I’m fine with the term Cτ,ss cause it is unambigous. IMHO, the term Ctrough shouldn’t be used at all.

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