blackwhite [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2019-02-04 15:34  – Posting: # 19862
Views: 2,960

Hi Nastia,

» […] By def Ctrough occurs at the end of dosing interval... I give up... It is impossible to distinguish!

Veto!
Look up trough in an English dictionary. A kind of minimum, right? The minimum (hence in the textbooks “Cmin”) can occur anywhere in the profile. If you have no lag-time the chance to observe it at the beginning and the end is 50% each (by definition).
I’m fine with the term Cτ,ss cause it is unambigous. IMHO, the term Ctrough shouldn’t be used at all.


Définissez les termes, vous dis-je, ou jamais nous ne nous entendrons.

Define your terms, you will permit me again to say, or we shall never understand one another.
Voltaire (Miracles, 1764)


Cheers,
Helmut Schütz
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