Bioequivalence and Bioavailability Forum • thoughtcrime

thoughtcrime [NCA / SHAM]

posted by Astea – Russia, 2019-02-04 15:13 – Posting: # 19861
Views: 3,128

» Common understanding: C_min,ss = C_trough, which is ≠ C_τ,ss in case of a lag-time. Even without a lag-time due to variability C_min,ss can be observed at the beginning or the end of the dosing interval. Sigh.

Come on! By def C_trough occurs at the end of dosing interval... I give up... It is impossible to distinguish!

—
"Being in minority, even a minority of one, did not make you mad"

Complete thread:

Steady state: Cmin / PTF Helmut 2011-03-08 15:30
- Steady state: Cmin / PTF SDavis 2012-02-06 14:00
  - Steady state: Cmin / PTF Helmut 2012-02-06 14:24
    - Is Cmin an atavism or not? Astea 2019-02-03 22:25
      - Originators | generics (Cmin | Cτ) Helmut 2019-02-04 13:18
        
        Down with Big Brother Astea 2019-02-04 13:51
        
        Down with Big Brother Helmut 2019-02-04 14:43
        
        thoughtcrimeAstea 2019-02-04 15:13
        
        blackwhite Helmut 2019-02-04 15:34
        
        animal farm Astea 2019-02-04 15:53