Try to find suitable PK model [PK / PD]

posted by mittyri – Russia, 2019-01-31 23:01  – Posting: # 19834
Views: 659

(edited by mittyri on 2019-01-31 23:30)

Hi,

» 1. Given the value of binding to plasma proteins and having the free concentration profiles for D1 and D2, would it be possible to calculate the total plasma concentration of D2 for each point, considering the free concentration in this dose at each time?

I would recommend to use some NONMEM/NLME/Monolix/Matlab/R skills to build an appropriate model(s). The model building process is not straightforward sometimes, but in case of success (successful validation and other signs of goodness of predicability) you'll get what you want.

» 2. If it is possible, and with total plasma concentration profile projected for D2, could we use compartmental analysis and, following two compartments, obtain A, B, alpha and beta macro-constants? From this point on, could we simulate other multiple dosing schedules (changing the interval between doses)?
The main question is: are you sure that 2-cmt model is applicable for your analyte? Are there any other investigations regarding that statement?
As I answered for the 1st question, if the model is finalized (so, the modeller realized that it suites the data well and have enough predicability level), all other questions are just peanuts for the modeller.

Kind regards,
Mittyri

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