AUCinf, MRT, Partial AUC [Software]
❝ When we do NCA we have obs and pred parameters. Which is better to use? Ex: AUCobs or AUCpred?
❝ When we do plasma and microdialysate experiments, but the time collections are not the same, for example, plasma collections was performed until 9 hr and microdialysis collections in tissue until 8.5 hr. Is it possible to compare the MRT in this case with different time of experiment?
In WNL wordings
MRTlast = AUMClast/AUClast (bolus case)
If the coverage of PK profile is enough, the estimation of MRT would be fair enough too.
❝ What about AUC? For AUC would be possible to extrapolate the concentration up to 9hr considering the k?
❝ When we calculate t1/2 and MRT after iv bolus dosing and these values are different, which could be the reasons if the k is not statistically different?
Thus since HL = ln(2)/kel
the distribution of parameters won't be the same.
Simple example in R
> t.test(1:10, y = c(7:20))
Welch Two Sample t-test
data: 1:10 and c(7:20)
t = -5.4349, df = 21.982, p-value = 1.855e-05
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
-11.052802 -4.947198
sample estimates:
mean of x mean of y
5.5 13.5
> t.test(log(2)/1:10, y = c(log(2)/7:20))
Welch Two Sample t-test
data: log(2)/1:10 and c(log(2)/7:20)
t = 2.3964, df = 9.1376, p-value = 0.03974
alternative hypothesis: true difference in means is not equal to 0
95 percent confidence interval:
0.008506605 0.283884254
sample estimates:
mean of x mean of y
0.20302061 0.05682518
Kind regards,
Mittyri
Complete thread:
- Phoenix Winnonlin PKBR 2019-01-25 18:27
- AUCinf, MRT, Partial AUCmittyri 2019-01-26 22:42
- AUCinf, MRT, Partial AUC PKBR 2019-01-28 18:54
- AUCinf, MRT, Partial AUCmittyri 2019-01-26 22:42