Interference from Deuterated IS [Bioanalytics]

posted by ElMaestro  – Denmark, 2019-01-11 10:49 (1904 d 00:07 ago) – Posting: # 19773
Views: 3,378

Hello chirag,

may I ask:

❝ 2.During method development we observed around 12-16% interference from Digoxin deuterated (D3) IS at the RT of Digoxin drug. There seems to be no source for D5 or D7 or D11.


Does the IS increase or decrease the area of the analyte?

❝ 4. Two different sources of Deuterated IS were tested and results are similar.


What is the purity expressed as DigD3 on your CoA's?

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
22,957 posts in 4,819 threads, 1,636 registered users;
115 visitors (0 registered, 115 guests [including 5 identified bots]).
Forum time: 10:57 CET (Europe/Vienna)

With four parameters I can fit an elephant,
and with five I can make him wiggle his trunk.    John von Neumann

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5