Calculation of time above MIC [R for BE/BA]

posted by Aceto81 – Belgium, 2008-06-26 16:31  – Posting: # 1973
Views: 23,731

Hi all,

I'm working at a small pharmaceutical company, and I'm doing my first (small) steps in the field of PK/PD.

I recieved an article from a collegue, which I should be able to reproduce
(article: PK and PK/PD of doxycycline in drinking water after therapeutic use in pigs, J. vet. Pharmacol. Therap. 28, 525-530, 2005.)

Cmax, Cmin, AUC, AUCss, I'm able to reproduce, but I'm struggling with the time above the MIC90 and %time above MIC90.

for example: if I have a MIC90 for Pasteurella multocida of 0.517µg/ml
and the following data:
 time  Subj   conc
  0.5   1     0.64
  1     1     0.7
  3     1     1.39
  5     1     1.35
  8     1     0.67
 12     1     1.48
 24     1     0.32
 36     1     2.08
 48     1     0.87
 60     1     0.93
 72     1     1.09
 84     1     0.59
 96     1     1.01
108     1     0.47
120     1     0.99
122     1     0.62
124     1     0.13


Prats et al. came up with a time of 102.5 hours and 94.9% of total time in SS.

I have no idea about how to find the 102.5 hours.
I searched in the forum's archive, in the manual of WinNonLin, on the web, but couldn't find any references.

Maybe someone can give me some help?
I'm routinely use R, but now I'm also using WinNonLin.


Thanks in advance

Ace

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Edit: Category changed; table reformated using BBCodes. [Helmut]

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