Bioequivalence and Bioavailability Forum

0.95 or 1.05 [Power / Sample Size]

posted by Helmut  – Vienna, Austria, 2018-10-10 15:41 (2018 d 06:30 ago) – Posting: # 19428
Views: 25,124

Hi Oleg,

❝ […] can you explain your message to my colleagues in russian here

Interesting thread (as far as translate took me). IIRC, some posters were not sure whether to use an assumed T/R-ratio of 0.95 or 1.05. Have a look at this post and that one. In short, if you assume a 5% difference but are not (very!) sure about the direction of the deviation (lower or higher than 100%), a study powered for 0.95 will always be sufficiently powered for 1.05 as well but not the other way ’round.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Power is getting high kms.srinivas 2017-12-26 07:39 [Power / Sample Size] 
  • Power is getting high? d_labes 2017-12-26 12:08
  • Stop estimating post hoc power! Helmut 2017-12-26 12:22
    • Stop estimating post hoc power! kms.srinivas 2017-12-26 13:00
      • Stop estimating post hoc power! ElMaestro 2017-12-26 14:11
      • Simulations Helmut 2017-12-26 15:51
        • Simulations BE-proff 2017-12-27 06:53
          • Simulations ElMaestro 2017-12-27 07:25
          • Simulations Yura 2017-12-27 08:23
            • Simulations kms.srinivas 2017-12-27 09:11
              • Simulations Yura 2017-12-27 10:07
                • α and 1–β Helmut 2017-12-27 12:57
                  • α and 1–β Yura 2017-12-27 13:33
                    • α and 1–β Helmut 2017-12-27 14:31
                      • α and 1–β Yura 2017-12-28 06:50
                        • Educate the IEC and regulators Helmut 2017-12-28 11:30
              • “Forced BE” 101 Helmut 2017-12-27 12:23
                • “Forced BE” 101 kms.srinivas 2017-12-27 12:41
                  • Would you be so kind answering our questions? Helmut 2017-12-27 13:02
                    • Would you be so kind answering our questions? kms.srinivas 2017-12-28 05:53
                      • Yes, but why? Helmut 2017-12-28 11:47
                        • Yes, but why? DavidManteigas 2017-12-28 16:59
                          • Optimists and pessimists Helmut 2017-12-28 17:33
                            • "normal" GMR setting d_labes 2017-12-28 18:57
                              • Example for discussion mittyri 2017-12-28 22:06
                                • Example for discussion Helmut 2017-12-28 22:33
                              • I prefer to play it safe Helmut 2017-12-28 22:10
                          • Full ACK d_labes 2017-12-28 17:41
                          • About GMR 1.10 kms.srinivas 2017-12-29 13:20
                            • Better 0.95 or 0.90 Helmut 2017-12-29 16:18
                        • Yes, but why? Yura 2017-12-29 13:46
                        • Buffon's needle Astea 2018-01-20 23:55
                          • Buffon's needle Oleg777 2018-10-09 22:48
                            • 0.95 or 1.05Helmut 2018-10-10 13:41
                          • Buffon's needle Helmut 2018-10-10 12:46
                            • Buffon's needle Astea 2018-10-11 23:14
                              • School maths Helmut 2018-10-12 01:10
                                • School russian Astea 2018-10-12 12:41
                                • Offtop: Umschrift der westlichen Eigennamen auf Russisch mittyri 2018-10-12 23:25
                    • EEU? mittyri 2017-12-28 21:52
                      • EEU? Yura 2017-12-29 13:41
                        • EEU - pharmacokinetic equation??? mittyri 2017-12-29 14:11
                      • EEU? Beholder 2018-01-16 15:10
          • Simulations xtianbadillo 2018-01-18 22:22
  • Numbers don't lie ElMaestro 2017-12-28 20:13