Calculation of AUC0-72 [NCA / SHAM]

posted by Ohlbe – France, 2008-06-10 17:28  – Posting: # 1935
Views: 20,005

Dear all,

» » How many minimum concentrations requried for calculation of t1/2 and Kel.
»
» For the estimation of kel 3, for the calculation of t1/2 zero. SCNR :-D

What is the point in calculating kel and t½, if you are using truncated AUC ?

If you are truncating your AUC at 72 h, it probably means that you have a drug with a long terminal half-life. The points you have till 72 hours may not be sufficient and adequate to provide a reliable estimate of kel.

Regards
Ohlbe

Complete thread:

Activity
 Admin contact
20,793 posts in 4,353 threads, 1,445 registered users;
online 24 (0 registered, 24 guests [including 11 identified bots]).
Forum time: 15:49 CEST (Europe/Vienna)

In God we trust;
all others must bring data.    W. Edwards Deming

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5