Calculation of AUC0-72 [NCA / SHAM]

posted by Ohlbe – France, 2008-06-10 17:28  – Posting: # 1935
Views: 18,658

Dear all,

» » How many minimum concentrations requried for calculation of t1/2 and Kel.
»
» For the estimation of kel 3, for the calculation of t1/2 zero. SCNR :-D

What is the point in calculating kel and t½, if you are using truncated AUC ?

If you are truncating your AUC at 72 h, it probably means that you have a drug with a long terminal half-life. The points you have till 72 hours may not be sufficient and adequate to provide a reliable estimate of kel.

Regards
Ohlbe

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