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RegisterCalculation of AUC0-72 [NCA / SHAM]
Dear all,
What is the point in calculating kel and t½, if you are using truncated AUC ?
If you are truncating your AUC at 72 h, it probably means that you have a drug with a long terminal half-life. The points you have till 72 hours may not be sufficient and adequate to provide a reliable estimate of kel.
Regards
Ohlbe
❝ ❝ How many minimum concentrations requried for calculation of t1/2 and Kel.
❝
❝ For the estimation of kel 3, for the calculation of t1/2 zero. SCNR 
What is the point in calculating kel and t½, if you are using truncated AUC ?
If you are truncating your AUC at 72 h, it probably means that you have a drug with a long terminal half-life. The points you have till 72 hours may not be sufficient and adequate to provide a reliable estimate of kel.
Regards
Ohlbe
Complete thread:
- Calculation of AUC0-72 Sasi 2008-06-10 10:44 [NCA / SHAM]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Calculation of AUC0-72 Jaime_R 2008-06-10 12:18
- Calculation of AUC0-72Ohlbe 2008-06-10 17:28
- Calculation of AUC0-72 Jaime_R 2008-06-10 18:45
- Regulators truncated d_labes 2009-06-18 09:26
- Regulators truncated Ohlbe 2009-06-18 10:37
- Regulators truncated Helmut 2009-06-18 14:49
- Regulators truncated d_labes 2009-06-18 15:26
- Regulators truncated Helmut 2009-06-18 15:44
- Regulators truncated ElMaestro 2009-06-19 22:16
- Regulators truncated Helmut 2009-06-19 22:35
- Regulators truncated ElMaestro 2009-06-19 22:16
- Regulators truncated Helmut 2009-06-18 15:44
- Regulators truncated d_labes 2009-06-18 15:26
- Luke 23:34 ElMaestro 2009-06-18 14:50
- Regulators truncated d_labes 2009-06-18 09:26
- Calculation of AUC0-72 d_labes 2008-09-05 15:00
- Calculation of AUC0-72 Helmut 2009-01-26 16:24
- Calculation of AUC0-72 d_labes 2009-01-26 16:57
- Calculation of AUC0-72 Helmut 2009-01-26 17:20
- The missing 72h d_labes 2009-01-27 11:48
- The missing 72h Ohlbe 2009-01-28 00:00
- sensitivity analyses ? martin 2009-01-28 08:26
- Regulators ways are inscrutable d_labes 2009-01-28 09:54
- Regulators ways are inscrutable (at least the French) Ohlbe 2009-01-28 10:16
- The missing 72h ElMaestro 2009-01-28 14:32
- Page 3848 of 221 d_labes 2009-01-28 14:51
- Partial AUC calculation Astea 2017-03-11 20:14
- Partial AUC calculation mittyri 2017-03-16 19:46
- The missing 72h Ohlbe 2009-01-28 00:00
- The missing 72h d_labes 2009-01-27 11:48
- Calculation of AUC0-72 Helmut 2009-01-26 17:20
- Calculation of AUC0-72 d_labes 2009-01-26 16:57
- Calculation of AUC0-72 Helmut 2009-01-26 16:24
- Calculation of AUC0-72 Jaime_R 2008-06-10 18:45
- Calculation of AUC0-72Ohlbe 2008-06-10 17:28
- Calculation of AUC0-72 PharmCat 2022-12-21 20:49
- Calculation of AUC0-72 Jaime_R 2008-06-10 12:18
Ing. Helmut Schütz