## Calculation of AUC0-72 [NCA / SHAM]

Hi Sasi!

» ... i need to calculate AUC0-72 instead of AUClast and AUCinf how can i calculate this value by using winnonlin.

I'm not sure whether I understand your question.

» How many minimum concentrations requried for calculation of t1/2 and Kel.

For the

» ... i need to calculate AUC0-72 instead of AUClast and AUCinf how can i calculate this value by using winnonlin.

I'm not sure whether I understand your question.

- If your study was planned to be evaluated with AUC
_{0-72}as the primary target parameter, I would expect that your last sampling time point was 72 hours - therefore AUC_{0-72}= AUC_{last}.

- If you have sampled for a longer time period and later on changed your mind (why?), you have to exclude these time points from calculations:

Assuming your sampling times are contained in a column named 'time' > click this column once > Data > Exclude > Criteria >

Write '72' in the field 'Find'

In the 'Search Area' select the second option 'Column: time'

In the 'Operation' field select '>'

Check [x] the box 'Exclude Row Matching Criteria'

Click 'Exclude'

Then proceed as usual in th BE-wiz.

» How many minimum concentrations requried for calculation of t1/2 and Kel.

For the

*of k***estimation**_{el}3, for the*of t***calculation**_{½}zero. SCNR—

Regards, Jaime

Regards, Jaime

### Complete thread:

- Calculation of AUC0-72 Sasi 2008-06-10 10:44
- Calculation of AUC0-72Jaime_R 2008-06-10 12:18
- Calculation of AUC0-72 Ohlbe 2008-06-10 17:28
- Calculation of AUC0-72 Jaime_R 2008-06-10 18:45
- Regulators truncated d_labes 2009-06-18 09:26
- Regulators truncated Ohlbe 2009-06-18 10:37
- Regulators truncated Helmut 2009-06-18 14:49
- Regulators truncated d_labes 2009-06-18 15:26
- Regulators truncated Helmut 2009-06-18 15:44
- Regulators truncated ElMaestro 2009-06-19 22:16
- Regulators truncated Helmut 2009-06-19 22:35

- Regulators truncated ElMaestro 2009-06-19 22:16

- Regulators truncated Helmut 2009-06-18 15:44

- Regulators truncated d_labes 2009-06-18 15:26
- Luke 23:34 ElMaestro 2009-06-18 14:50

- Regulators truncated d_labes 2009-06-18 09:26
- Calculation of AUC0-72 d_labes 2008-09-05 15:00
- Calculation of AUC0-72 Helmut 2009-01-26 16:24
- Calculation of AUC0-72 d_labes 2009-01-26 16:57
- Calculation of AUC0-72 Helmut 2009-01-26 17:20
- The missing 72h d_labes 2009-01-27 11:48
- The missing 72h Ohlbe 2009-01-28 00:00
- sensitivity analyses ? martin 2009-01-28 08:26
- Regulators ways are inscrutable d_labes 2009-01-28 09:54
- Regulators ways are inscrutable (at least the French) Ohlbe 2009-01-28 10:16

- The missing 72h ElMaestro 2009-01-28 14:32
- Page 3848 of 221 d_labes 2009-01-28 14:51

- Partial AUC calculation Astea 2017-03-11 20:14
- Partial AUC calculation mittyri 2017-03-16 19:46

- The missing 72h Ohlbe 2009-01-28 00:00

- The missing 72h d_labes 2009-01-27 11:48

- Calculation of AUC0-72 Helmut 2009-01-26 17:20

- Calculation of AUC0-72 d_labes 2009-01-26 16:57

- Calculation of AUC0-72 Helmut 2009-01-26 16:24

- Calculation of AUC0-72 Jaime_R 2008-06-10 18:45

- Calculation of AUC0-72 Ohlbe 2008-06-10 17:28

- Calculation of AUC0-72Jaime_R 2008-06-10 12:18