100% included in 90% CI? [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-07-12 11:09  – Posting: # 19038
Views: 1,353

Hi libaiyi,

» The output of a BE study shows that the confidence interval of all three PK parameters are between 80%-125%. But the p value of AUC0-t's treatment effect is bigger than 0.05, which is in contrast to the conclusion from CI, …

I don’t see a contradiction. If the 90% CI contains 100%, the p value will always be >0.05. Only if not, it may be <0.05 (see this lengthy thread).

» … and the period effect and carryover effect are all proved equal.

You can’t prove anything with statistics. Do you mean that the p values are not significant?

Cheers,
Helmut Schütz
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