Bioequivalence and Bioavailability Forum 01:11 CEST

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

BA/BE study - internal standard response variability [Bioanalytics]

posted by avinash - India, 2018-07-11 06:44  - Posting: # 19028
Views: 648

Dear Members,
In BA/BE study bio-analysis, is high internal standard response variability is a cause for LC-MS data batch rejection? (for example more than 20% of the unknown samples showing more than ±50% difference etc..)
General practice is only one scenario is considered for IS variation (±50% difference from the mean), is there any other scenario to be considered?
Trend analysis for Internal standard area response? Please comment.
Thanks & regards,
Avinash Jain M V

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,697 posts in 3,982 threads, 1,238 registered users;
online 7 (0 registered, 7 guests [including 7 identified bots]).

Science should always be the basis
of regulatory requirements.    Joachim Röhmel

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed