Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

Back to the forum  2018-07-16 07:21 CEST (UTC+2h)

BA/BE study - internal standard response variability [Bioanalytics]

posted by avinash - India, 2018-07-11 06:44  - Posting: # 19028
Views: 206

Dear Members,
In BA/BE study bio-analysis, is high internal standard response variability is a cause for LC-MS data batch rejection? (for example more than 20% of the unknown samples showing more than ±50% difference etc..)
General practice is only one scenario is considered for IS variation (±50% difference from the mean), is there any other scenario to be considered?
Trend analysis for Internal standard area response? Please comment.
Thanks & regards,
Avinash Jain M V

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,527 posts in 3,938 threads, 1,190 registered users;
online 43 (0 registered, 43 guests [including 25 identified bots]).

Mankind has survived all catastrophes.
It will also survive modern medicine.    Gerhard Kocher

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed