In-line filter Vs filter at end of sampling probe [Dissolution / BCS / IVIVC]

posted by Obinoscopy  – Nigeria, 2018-07-09 15:15  – Posting: # 19026
Views: 1,713

Hi guys,

Please I need an explanation on what is the difference between an in-line filter and filter at end of sampling probe.

I saw a dissolution methodology which stated thus:

"...tablet was placed into a dissolution medium and then 5ml of dissolution was withdrawn at the stipulated time and immediately filtered through a syringe filter."

This methodology was queried by seasoned regulators. They requested that the filters should be in-line or at the end of the sampling probe or both.

What do they mean by that statement? Isn't that syringe filter considered as an in-filter? What do they mean by filter at end of sampling probe? What's the difference between an in-line filter and a filter at end of sampling probe?

I will really appreciate an assistance with this puzzle.

Regards.

Scopy

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,404 posts in 4,122 threads, 1,323 registered users;
online 7 (1 registered, 6 guests [including 4 identified bots]).
Forum time (Europe/Vienna): 16:54 UTC

No rational argument will have a rational effect on a man
who does not want to adopt a rational attitude.    Karl R. Popper

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5