Bioequivalence and Bioavailability Forum

Old belives die hard [General Sta­tis­tics]

posted by d_labes  – Berlin, Germany, 2018-07-04 15:28 (2121 d 18:02 ago) – Posting: # 19020
Views: 12,401

Dear Detlew,

❝ ❝ IMHO we don't need an alpha correction for your case above, if we combine the tests with 'and'.

❝ THX for reminding me (not for the first time)…

Correct.
But old belives die hard

❝ ❝ Eventually we can miss-use power.2TOST() ...

❝ ❝ Then of course the question of the correlation parameter rho arises. How to choose?

❝ Not sure. Whereas two PK metrics are always correlated somehow, IMHO, here it may be different. One formulation doesn’t care how it behaves in relation to the other...

Sounds for me like rho=0 .

Complete thread:

• Decision of confidence interval of three period BE study libaiyi 2018-06-26 12:00 [General Sta­tis­tics] 
  • Two tests and one reference Helmut 2018-06-26 13:13
    • Two tests and one reference Brus 2020-08-31 09:58
      • Two tests and one reference ElMaestro 2020-08-31 10:23
      • Two regions: No α adjustment Helmut 2020-08-31 10:26
        • Two regions: No α adjustment Brus 2020-08-31 11:09
          • Two regions: different populations Helmut 2020-08-31 11:26
  • Decision of confidence interval of three period BE study ElMaestro 2018-06-26 22:20
    • Any of two tests and one reference Helmut 2018-06-27 00:33
      • Any of two tests and one reference libaiyi 2018-06-27 08:25
      • Hey wait a moment.... ElMaestro 2018-06-27 08:29
        • Hey wait a moment.... Helmut 2018-06-27 11:45
          • Pilot or pivotal ? Ohlbe 2018-06-27 12:14
            • Pilot or pivotal ? ElMaestro 2018-06-27 13:01
              • Pilot or pivotal ? Ohlbe 2018-06-27 14:13
                • Pilot or pivotal ? ElMaestro 2018-06-27 14:48
                  • Pilot or pivotal ? Ohlbe 2018-06-27 15:43
                    • Pilot or pivotal ? ElMaestro 2018-06-27 22:13
            • Pilot or pivotal ? jag009 2018-06-29 20:53
              • Pilot or pivotal ? ElMaestro 2018-06-29 22:11
                • Pilot or pivotal ? jag009 2018-07-03 17:38
          • Hey, hey wait another moment.... d_labes 2018-06-28 19:48
            • Hey, hey wait another moment.... Helmut 2018-07-03 17:22
              • Old belives die hardd_labes 2018-07-04 13:28