Any of two tests and one reference [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-06-27 00:33  – Posting: # 18970
Views: 4,858

Hi ElMaestro,

» » […] if the goal is to prove the equivalence of any two of them (T1 and R or T2 and R).
»
» Due to the little word highlighted in red above I am fairly sure I would not apply any other alpha than 5%, meaning I would go with the usual 90% CIs. :-)

Good point – I missed that! In the past I did not adjust because only one will be marketed (i.e., the entire patient’s risk lies with this product). However, some regulatory statisticians (you know, coffee break chats) seem to be more strict because one gets two chances of passing. Too lazy to crawl the supplementary material of your paper about pilot studies: Is such a case covered?

Cheers,
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
20,258 posts in 4,264 threads, 1,400 registered users;
online 18 (0 registered, 18 guests [including 14 identified bots]).
Forum time (Europe/Vienna): 06:50 CET

Science is simply common sense at its best that is,
rigidly accurate in observation, and
merciless to fallacy in logic.    Thomas Henry Huxley

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5