Reliable estimates? [NCA / SHAM]

posted by Helmut Homepage – Vienna, Austria, 2018-06-20 01:12  – Posting: # 18925
Views: 1,087

Hi Babe_Ruth,

» I read in a PK report: "Where less than 3 quantifiable concentrations, AUC is not reported."

Bad English?

» The way I see it, if you only have two sequential concentrations above quantifiable limit, then you can generate a Tmax, but you can't be sure of the accuracy of Tmax, especially if Cmax is barely above quantitation limit of the assay used.

I know that some people report “Cmax” based on two concentrations and “AUC” on three. IMHO, that’s crap. I don’t belong to the club of guideline-addicts butI leave it you counting words like sufficient, reliable, appropriate, accurate

Cheers,
Helmut Schütz
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