Get software! [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-06-12 18:54 (2115 d 18:26 ago) – Posting: # 18891
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Hi Shawn,

❝ I am a fresher to BE analysis.


Welcome to the club!

❝ […] how to calculate the MSE_w and MSE_B for 2 X 2 crossover design and fully replicated design (TRT|RTR or TRTR|RTRT).


Thanks for not mentioning the lousy partial replicate (TRR|RTR|RRT). ;-)

❝ Could anyone tell me the detail of calculation for these different designs?


Do you want to calculate it manually (paper, pencil, brain)? A nice morning exercise as long as you have only fixed effects in the model (ANOVA).*
If you are interested in full-blown mixed-effects models (e.g., the FDA’s or the CFDA’s for reference-scaling), forget it. This would require restricted maximum likelihood estimation, which is – practically – impossible without software.

Given all that, get suitable software, validate it, and be happy. The residual mean squares are part of the standard output (example of a 2×2 design).



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