Get software! [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-06-12 16:54  – Posting: # 18891
Views: 2,929

Hi Shawn,

» I am a fresher to BE analysis.

Welcome to the club!

» […] how to calculate the MSE_w and MSE_B for 2 X 2 crossover design and fully replicated design (TRT|RTR or TRTR|RTRT).

Thanks for not mentioning the lousy partial replicate (TRR|RTR|RRT). ;-)

» Could anyone tell me the detail of calculation for these different designs?

Do you want to calculate it manually (paper, pencil, brain)? A nice morning exercise as long as you have only fixed effects in the model (ANOVA).*
If you are interested in full-blown mixed-effects models (e.g., the FDA’s or the CFDA’s for reference-scaling), forget it. This would require restricted maximum likelihood estimation, which is – practically – impossible without software.

Given all that, get suitable software, validate it, and be happy. The residual mean squares are part of the standard output (example of a 2×2 design).



Cheers,
Helmut Schütz
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