Bioequivalence and Bioavailability Forum • Stop estimating post hoc power!

Stop estimating post hoc power! [Power / Sample Size]

posted by valivetiananth – India, 2018-06-02 10:52 (2153 d 00:48 ago) – Posting: # 18841
Views: 7,179

Thanks for your reply.

❝ ❝ We have conducted a pivotal study for Europe with 48 subjects considering ~80% power, ISCV: 23%.

❝ ❝ The study was bioequivalent and 90% CI is within 80-125 for both Cmax & AUCt.

❝ ❝ Power of Cmax and AUCt are 92% & 66% respectively.

❝

❝ In this order? Can you give us their CVs and GMRs?

CV- Cmax: 27.731; AUCt: 22.678

GMR-Cmax: 97.76; AUCt: 87.99

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

Power in the pivotal study (EU) valivetiananth 2018-05-31 13:49
- Stop estimating post hoc power! Helmut 2018-05-31 14:45
  - Stop estimating post hoc power! ElMaestro 2018-05-31 15:43
    - Confession Helmut 2018-05-31 17:16
      - Confession ElMaestro 2018-05-31 21:47
        
        Confession Helmut 2018-06-01 00:01
        
        Confession ElMaestro 2018-06-01 08:31
        
        Silly-O-Meter: Syntax Helmut 2018-06-01 13:42
        
        Silly-O-Meter: Syntax ElMaestro 2018-06-01 15:17
  - Stop estimating post hoc power!valivetiananth 2018-06-02 08:52
    - Eligible subjects? Helmut 2018-06-02 13:02
    - Don’t we deserve an answer? Helmut 2018-06-09 15:13