Bioequivalence and Bioavailability Forum

Stop estimating post hoc power! [Power / Sample Size]

posted by ElMaestro  – Denmark, 2018-05-31 17:43 (2155 d 09:09 ago) – Posting: # 18834
Views: 7,484

Hi Hötzi,

❝ If a European assessor demands it (extremely unlikely!), ask where post hoc power is required in any of the current guidelines and suggest in a polite way to browse through my lectures (e.g., this pretty old one) or to attend training in basic biostatistics.

I don't mean to derail this thread. Only I must make a confession about it: When I assessed my very first BE-dossier I asked for post-hoc power and justification and I felt divine . Today I am not very proud of it. It was not until I had worked on this BE-stuff for years that it started dawning on me how post-hoc power is irrelevant (in spite of excellent presentations about it being freely available on the bebac.at website, of course).

There. Now I confessed. I sense a kind of relief.

Complete thread:

• Power in the pivotal study (EU) valivetiananth 2018-05-31 13:49 [Power / Sample Size] 
  • Stop estimating post hoc power! Helmut 2018-05-31 14:45
    • Stop estimating post hoc power!ElMaestro 2018-05-31 15:43
      • Confession Helmut 2018-05-31 17:16
        • Confession ElMaestro 2018-05-31 21:47
          • Confession Helmut 2018-06-01 00:01
            • Confession ElMaestro 2018-06-01 08:31
              • Silly-O-Meter: Syntax Helmut 2018-06-01 13:42
                • Silly-O-Meter: Syntax ElMaestro 2018-06-01 15:17
    • Stop estimating post hoc power! valivetiananth 2018-06-02 08:52
      • Eligible subjects? Helmut 2018-06-02 13:02
      • Don’t we deserve an answer? Helmut 2018-06-09 15:13