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Imbalance dataset analysis with Equivtest 2.0 [Software]

posted by Irene_I - Indonesia, 2018-05-16 09:02  - Posting: # 18768
Views: 376

Dear all,
My name is Irene and I'm a newcomer in bioequivalence fields. I would like to ask some question about imbalanced datasets. I have a problem in analyzing 2-treatment, 2-sequence, 2-period crossover bioequivalence study design with imbalanced datasets between sequence.

I have looked for this topics and I found a similar problem here but It seems like nothing has concluded. I'm Sorry but I still do not understand about it.

I conducted a data analysis for imbalance datasets from a journal entitled "Reference Dataset for 2-Treatment, 2-sequence, 2-period bioequivalence studies" (Dataset C) with EquivTest 2.0 and I compared the results with the ones stated in journal. I found that Equivtest 2.0 result (Point of estimate and 90% Confidence Interval) was not identical with EquivTest/PK (the result that stated in the journal). My Equivtest 2.0 result for point of estimates and confidence interval were:

point of estimate (90% CI) : 66.78 (44.94,99.24)

The result according to Journal (EquivTest/PK)
point of estimate (90% CI) : 58.56 (39.41,87.03)


So, is there someone could help me with this problem? :confused:

I strongly appreciate if you could help me about this matter. :-)

Best Regards,


Irene

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