Steady State design [Design Issues]
I have some doubts in designing study state protocols.
how to fix number of days to dosing
how to fix number of doses per day
My regular practice is if label/smpc states achievement of steady-state concentrations by the fifth day of once-a-day dosing for Tamsulosin, i will design the study state protocol with once a day dosing for five days. but i want to know the exact scientific rationale behind this.
please help me...
Edit: Category changed; see also this post #1. [Helmut]