Zero Sample Preparation [Bioanalytics]

posted by Obinoscopy  – Nigeria, 2018-04-15 02:19  – Posting: # 18682
Views: 1,867

(edited by Obinoscopy on 2018-04-15 02:44)

Hi guys,

How is the zero sample prepared? I know the blank sample is a biological matrix without the analyte and its internal standard. I also know the non zero samples are biological matrix spiked with a particular concentration of the analyte and same concentration of the internal standard.

The zero sample is a biological matrix spiked with the internal standard only. My question is this: What is the actual concentration of the internal standard that should be used to prepare the zero sample?

Obinoscopy

Scopy

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,302 posts in 4,102 threads, 1,317 registered users;
online 13 (1 registered, 12 guests [including 5 identified bots]).

Restlessness is discontent –
and discontent is the first necessity of progress.
Show me a thoroughly satisfied man –
and I will show you a failure.    Thomas Alva Edison

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5