What is clinically relevant? [Design Issues]
Dear Helmut:
I believe the spaghetti plots you posted are actually indicative of a infusion of unbound drug.
Release of the encapsulated form follows first order kinetics and is Sequential - kind of like metabolic clearance from parent --> metabolite.
Luckily, you also posted the parent/metabolite curve for doxorubinol. Because of similarity in process, if no free drug is infused, bound and unbound PK should follow the same general shape we see in parent + metabolite.
The fact that total + free dox concentrations are colinear is pretty strong evidence for co-infusion of bound + unbound. Further, the fact that there isn't a lag time in unbound, as well as a nonlinear shape, is evidence, too.
Thanks,
BF
I believe the spaghetti plots you posted are actually indicative of a infusion of unbound drug.
Release of the encapsulated form follows first order kinetics and is Sequential - kind of like metabolic clearance from parent --> metabolite.
Luckily, you also posted the parent/metabolite curve for doxorubinol. Because of similarity in process, if no free drug is infused, bound and unbound PK should follow the same general shape we see in parent + metabolite.
The fact that total + free dox concentrations are colinear is pretty strong evidence for co-infusion of bound + unbound. Further, the fact that there isn't a lag time in unbound, as well as a nonlinear shape, is evidence, too.
Thanks,
BF
Complete thread:
- Counterintuitive? nobody 2018-04-03 11:16
- Counterintuitive? bebac_fan 2018-04-03 18:20
- Counterintuitive? nobody 2018-04-03 23:25
- Counterintuitive? bebac_fan 2018-04-04 00:43
- Counterintuitive? nobody 2018-04-04 11:03
- Counterintuitive? bebac_fan 2018-04-04 00:43
- What is clinically relevant? Helmut 2018-04-04 16:49
- What is clinically relevant? nobody 2018-04-05 10:04
- What is clinically relevant? bebac_fan 2018-04-05 14:19
- What is clinically relevant? nobody 2018-04-06 09:22
- What is clinically relevant? Helmut 2018-04-06 16:10
- What is clinically relevant?bebac_fan 2018-04-06 20:53
- What is clinically relevant? Helmut 2018-04-06 22:05
- Korsmeyer–Peppas’ model mittyri 2018-04-06 23:36
- What is clinically relevant? Helmut 2018-04-06 22:05
- What is clinically relevant?bebac_fan 2018-04-06 20:53
- Counterintuitive? nobody 2018-04-03 23:25
- Counterintuitive? bebac_fan 2018-04-03 18:20