What is clinically relevant? [Design Issues]
Hi Felix Austria!
Yeah, it's complicated, no question. PEG-ylated, non-PEG-ylated on top. Maybe this i.v. modified release formulations are as complicated as inhalative stuff...
But what I was asking for is the finding of the paper that depending on the T/R of the release rate the most appropriate/sensitive parameter should vary. Is that real or not? I can't make sense out of this (without reading the original paper, no 41.59 € worth for me...).
Let's say: if T releases faster than R, take AUCpart 0-24h. But if I switch T and R the same does not apply. Why that? I don't get it....
Yeah, it's complicated, no question. PEG-ylated, non-PEG-ylated on top. Maybe this i.v. modified release formulations are as complicated as inhalative stuff...
But what I was asking for is the finding of the paper that depending on the T/R of the release rate the most appropriate/sensitive parameter should vary. Is that real or not? I can't make sense out of this (without reading the original paper, no 41.59 € worth for me...).
Let's say: if T releases faster than R, take AUCpart 0-24h. But if I switch T and R the same does not apply. Why that? I don't get it....
—
Kindest regards, nobody
Kindest regards, nobody
Complete thread:
- Counterintuitive? nobody 2018-04-03 11:16 [Design Issues]
- Counterintuitive? bebac_fan 2018-04-03 18:20
- Counterintuitive? nobody 2018-04-03 23:25
- Counterintuitive? bebac_fan 2018-04-04 00:43
- Counterintuitive? nobody 2018-04-04 11:03
- Counterintuitive? bebac_fan 2018-04-04 00:43
- What is clinically relevant? Helmut 2018-04-04 16:49
- What is clinically relevant?nobody 2018-04-05 10:04
- What is clinically relevant? bebac_fan 2018-04-05 14:19
- What is clinically relevant? nobody 2018-04-06 09:22
- What is clinically relevant? Helmut 2018-04-06 16:10
- What is clinically relevant? bebac_fan 2018-04-06 20:53
- What is clinically relevant? Helmut 2018-04-06 22:05
- Korsmeyer–Peppas’ model mittyri 2018-04-06 23:36
- What is clinically relevant? Helmut 2018-04-06 22:05
- What is clinically relevant? bebac_fan 2018-04-06 20:53
- Counterintuitive? nobody 2018-04-03 23:25
- Counterintuitive? bebac_fan 2018-04-03 18:20