Bioequivalence and Bioavailability Forum 18:49 CEST

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log in |  Register |  Search

LSMeans [General Sta­tis­tics]

posted by ElMaestro - Denmark, 2018-02-27 09:02  - Posting: # 18469
Views: 1,611

Sorry about this,

I am a bit backward.

Once again I would like to raise the wonderful topic of LSMeans.
They are a SAS invention and I am still not sure I have truly understood what the hell they really are. Or more correctly, I am very sure I have no clue whatsoever about them.
Now, before someone throws a handful of web pages at me, I want to assure you, I have read them already. I am posting this because I still don't get it after all that reading e.g. here, here , and here.

The recent question about baseline adjustment and covariates in this forum made me try to understand LSMeans again. So I have been sleepless since then, of course. Shouldn't have done it. But that's hindsight.

For example: "When covariates are present in the model, the LSMEANS statement produces means which are adjusted for the average value of the specified covariate(s)."
I have no friggin clue what that really means.

Can someone, without using package lsmeans in R or automated tools, explain in slowmotion me what LSMeans really are and how exactly you would go about deriving LSMeans from scratch in a concrete dataset given a model? Feel free to use the code in the thread mentioned above as a starting point, this would ease my understanding.

Muchas gracias.


Edit: Category changed; see also this post #1. [Helmut]

if (3) 4

Best regards,
ElMaestro

"(...) targeted cancer therapies will benefit fewer than 2 percent of the cancer patients they’re aimed at. That reality is often lost on consumers, who are being fed a steady diet of winning anecdotes about miracle cures." New York Times (ed.), June 9, 2018.

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
18,700 posts in 3,984 threads, 1,241 registered users;
online 12 (0 registered, 12 guests [including 10 identified bots]).

When puzzled, it never hurts to read the primary documents –
a rather simple and self-evident principle that has, nonetheless,
completely disappeared from large sectors
of the American experience.    Stephen Jay Gould

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5 RSS Feed