Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2018-03-24 12:43 CET (UTC+1h)

LSMeans [General Sta­tis­tics]

posted by ElMaestro - Denmark, 2018-02-27 09:02  - Posting: # 18469
Views: 856

Sorry about this,

I am a bit backward.

Once again I would like to raise the wonderful topic of LSMeans.
They are a SAS invention and I am still not sure I have truly understood what the hell they really are. Or more correctly, I am very sure I have no clue whatsoever about them.
Now, before someone throws a handful of web pages at me, I want to assure you, I have read them already. I am posting this because I still don't get it after all that reading e.g. here, here , and here.

The recent question about baseline adjustment and covariates in this forum made me try to understand LSMeans again. So I have been sleepless since then, of course. Shouldn't have done it. But that's hindsight.

For example: "When covariates are present in the model, the LSMEANS statement produces means which are adjusted for the average value of the specified covariate(s)."
I have no friggin clue what that really means.

Can someone, without using package lsmeans in R or automated tools, explain in slowmotion me what LSMeans really are and how exactly you would go about deriving LSMeans from scratch in a concrete dataset given a model? Feel free to use the code in the thread mentioned above as a starting point, this would ease my understanding.

Muchas gracias.

Edit: Category changed; see also this post #1. [Helmut]

I could be wrong, but…

Best regards,

- Bootstrapping for dissolution data is a relatively new hobby of mine.

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum | Admin contact
18,075 Posts in 3,845 Threads, 1,140 registered users;
29 users online (0 registered, 29 guests).

It is better to be wrong than to be vague.
In trial and error, the error is the true essential.    Freeman Dyson

BEBAC Ing. Helmut Schütz