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RegisterSo you made a baseline correction and now the team discusses ANCOVA [General Statistics]
Dear Everbody,
Dealing with endogenous compounds is tricky and here are some more thoughts you may find helpful
This could be considered as change from baseline problem and you may have a look at Stephen Senns work on this topic relating to ANCOVA (e.g. Statist. Med. 2006; 25:4334–4344. https://doi.org/10.1002/sim.2682 )
You may find also this article of interest addressing adjustment of endogenous levels in PK modeling: Bauer, A. & Wolfsegger, M.J. Eur J Clin Pharmacol (2014) 70: 1465. https://doi.org/10.1007/s00228-014-1759-x
Best regards & hope this helps
Martin
Dealing with endogenous compounds is tricky and here are some more thoughts you may find helpful
This could be considered as change from baseline problem and you may have a look at Stephen Senns work on this topic relating to ANCOVA (e.g. Statist. Med. 2006; 25:4334–4344. https://doi.org/10.1002/sim.2682 )
You may find also this article of interest addressing adjustment of endogenous levels in PK modeling: Bauer, A. & Wolfsegger, M.J. Eur J Clin Pharmacol (2014) 70: 1465. https://doi.org/10.1007/s00228-014-1759-x
Best regards & hope this helps
Martin
Complete thread:
- So you made a baseline correction and now the team discusses ANCOVA Relaxation 2018-02-13 15:37
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