Bioequivalence and Bioavailability Forum

Main page Policy/Terms of Use Abbreviations Latest Posts

 Log-in |  Register |  Search

Back to the forum  Query: 2018-05-21 13:04 CEST (UTC+2h)
 

Put the sickle to the corn [General Sta­tis­tics]

posted by Helmut Homepage - Vienna, Austria, 2018-02-13 12:45  - Posting: # 18412
Views: 2,070

Hi Nastia,

» I didn't want to doubt into results of your study,

No worries. I was curious myself.

» just wanted to point out that the results of miscorrelation between Cmax and AUC should be more dependent on the features of the specific study than on the drug itself.

Or the dose regimen (as Relaxation suspected)?

» […] is sampling time is adequate but comparing to the less rapid drug the difference in 30 minutes in elimination phase could give sufficiently more error in calculating AUC (one day for jinn as thousand years for man)?

:-D

» The last question about it: what was the mean T1/2 (from these abrupt profiles I may suspect less than known in literature 20 minutes)?

Linear plot with enlarged time scale:

[image]

Your wish is my command. Data cemetery:
     tlag        tmax        t½         Cmax          AUCt           AUCext
T  5 (0, 5)  40 (30, 57) 
22 (6.5)  5.36 (24.3)  6.03 (15.6)  6.37 (5.81, 6.94)
R  5 (0, 5)  35 (30, 50) 
23 (5.2)  5.03 (25.9)  5.48 (21.0)  5.45 (4.89, 6.73)

tlag, tmax minutes; median (quartiles)
t½         minutes; harmonic mean (jacknife SD)
Cmax       µg/mL; geometric mean (CV%)
AUCt       h×µg/mL; geometric mean (CV%)
AUCext     100(AUCt–AUC)/AUC; median (quartiles)

[image]Cheers,
Helmut Schütz 
[image]

The quality of responses received is directly proportional to the quality of the question asked. ☼
Science Quotes

Complete thread:

Back to the forum Activity
 Mix view
Bioequivalence and Bioavailability Forum | Admin contact
18,269 posts in 3,882 threads, 1,161 registered users;
13 users online (0 registered, 13 guests).

Science is wonderfully equipped to answer the question “How?”
but it gets terribly confused when you ask the question “Why?”    Erwin Chargaff

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
XHTML/CSS RSS Feed