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Put the sickle to the corn [General Sta­tis­tics]

posted by Astea - Russia, 2018-02-13 08:27  - Posting: # 18410
Views: 7,267

Dear Helmut!

» I recalculated the entire study (October 1997!) from raw-data (nasty!).

Very sorry about that! I didn't want to doubt into results of your study, just wanted to point out that the results of miscorrelation between Cmax and AUC should be more dependent on the features of the specific study than on the drug itself.

» Maximum residual AUC in any of the 24 subjects 7%.

Is it possible to expect large AUCresid for ASA when sampling time is 12 hours?

» Hhm. 00:05, 00:10...

That's perfect. But than may it be connected with fast elimination of ASA? That is sampling time is adequate but comparing to the less rapid drug the difference in 30 minutes in elimination phase could give sufficiently more error in calculating AUC (one day for jinn as thousand years for man)?
The last question about it: what was the mean T1/2 (from these abrupt profiles I may suspect less than known in literature 20 minutes)?

» may I call you Nasty as well?

I would prefer Nastia (that was Nabokov who first pointed out the similar pronounciation)

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One can show the following: given any rule, however “fundamental”
or “necessary” for science, there are always circumstances
when it is advisable not only to ignore the rule,
but to adopt its opposite.    Paul Feyerabend

BEBAC Ing. Helmut Schütz