Bioequivalence and Bioavailability Forum

Put the sickle to the corn [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2018-02-13 02:37 (2257 d 02:59 ago) – Posting: # 18409
Views: 15,114

Dear Astea,

may I call you Nasty as well?

❝ I may suppose there were some problems in your Acetylsalicylic acid study - may be in stability…

Samples put in an ice-bath until centrifugation, plasma diluted 1:1 with 5% o-phosphoric acid for stabilization.

❝ … or inadequate sampling time,

Hhm. 00:05, 00:10, 00:15, 00:20, 00:30, 00:40, 00:50, 01:00, 01:20, 01:40, 02:00, 02:30, 03:00, 04:00, 06:00, 08:00, 10:00, 12:00 hours. No problems with "first point C_max".

❝ … did you measure also salicylic acid?

Sure. Nice rho (see in the list above).

❝ What was the dose?

100 mg ASA (actually 5 × 20 mg tablets).

I recalculated the entire study (October 1997!) from raw-data (nasty!). Maximum residual AUC in any of the 24 subjects 7%. CV_intra: ASA 18.3% (C_max), 11.8% (AUC_0–t); SA 9.58% (C_max), 8.71% (AUC_0–t). Both ASA and SA passed BE with flying colors.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Science Quotes

Complete thread:

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        • ρ ρ ρ your boat Helmut 2018-02-09 19:20
      • ...and a bonus question ElMaestro 2018-02-09 11:32
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          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
            • The mysterious ρ within studies Helmut 2018-02-11 22:44
              • The mysterious ρ within studies nobody 2018-02-12 09:08
        • The mysterious ρ -between or within studies Astea 2018-02-11 17:34
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
          • The mysterious ρ within studies Helmut 2018-02-11 22:48
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
    • Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
      • reminds me of something ElMaestro 2018-02-12 09:18
        • reminds me of something nobody 2018-02-12 09:38
          • Hammer to fall Astea 2018-02-12 18:37
            • Put the sickle to the cornHelmut 2018-02-13 01:37
              • Put the sickle to the corn Astea 2018-02-13 08:27
                • Put the sickle to the corn Helmut 2018-02-13 12:45
              • Put the sickle to the corn Relaxation 2018-02-13 10:37
                • multiple units, lag-times Helmut 2018-02-13 13:31