The mysterious ρ within studies [General Sta­tis­tics]

posted by Helmut Homepage – Vienna, Austria, 2018-02-11 22:48  – Posting: # 18402
Views: 8,656

Dear Astea!

» The intermediate question is mentioned situation about parent drug and its metabolite - logically, the correlation for the parameters of parent drug and its metabolite should be stronger than for two different drugs tested on the same population?

Oh dear, yes! But that’s yet another story.

» 1e+06 simulations. Time consumed (secs)
»    user  system elapsed
» 979.75   95.18 1115.72

Get a faster machine! My almost three years old tin-can:
1e+06 simulations. Time consumed (secs)
   user  system elapsed
 208.64   31.17  240.75


» Do I understand correctly that in your latest code you exployed all AUC and Cmax individual data for each study in order to estimate "within rho"?

Yes. Apples and oranges. See there for a breakdown by analyte.

Cheers,
Helmut Schütz
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