Bioequivalence and Bioavailability Forum

The mysterious ρ within studies [General Statistics]

posted by Helmut – Vienna, Austria, 2018-02-11 23:48 (2258 d 19:06 ago) – Posting: # 18402
Views: 15,466

Dear Astea!

❝ The intermediate question is mentioned situation about parent drug and its metabolite - logically, the correlation for the parameters of parent drug and its metabolite should be stronger than for two different drugs tested on the same population?

Oh dear, yes! But that’s yet another story.

❝ 1e+06 simulations. Time consumed (secs)

❝ user system elapsed

❝ 979.75 95.18 1115.72

Get a faster machine! My almost three years old tin-can:

1e+06 simulations. Time consumed (secs)

   user  system elapsed

 208.64   31.17  240.75

❝ Do I understand correctly that in your latest code you exployed all AUC and Cmax individual data for each study in order to estimate "within rho"?

Yes. Apples and oranges. See there for a breakdown by analyte.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Power and type I adjustment for 222BE when several PK prams considered Louis52 2018-02-07 21:04 [General Statistics]
- Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-07 22:37
- Power of two combined TOST d_labes 2018-02-08 14:12
  - The mysterious ρ Helmut 2018-02-08 21:40
    - ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
      - ρ ρ ρ your boat Helmut 2018-02-09 19:20
    - ...and a bonus question ElMaestro 2018-02-09 11:32
      - ...and a bonus question Helmut 2018-02-09 19:43
        
        If u see a BEar don't forget to R oaρ Astea 2018-02-09 20:47
        
        package install failed d_labes 2018-02-11 13:23
    - The mysterious ρ -between or within studies d_labes 2018-02-11 15:57
      - The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
        
        The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
        
        The mysterious ρ within studies Helmut 2018-02-11 22:44
        
        The mysterious ρ within studies nobody 2018-02-12 09:08
      - The mysterious ρ -between or within studies Astea 2018-02-11 17:34
        
        The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
        The mysterious ρ within studiesHelmut 2018-02-11 22:48
- Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
  - Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
    - reminds me of something ElMaestro 2018-02-12 09:18
      - reminds me of something nobody 2018-02-12 09:38
        
        Hammer to fall Astea 2018-02-12 18:37
        
        Put the sickle to the corn Helmut 2018-02-13 01:37
        
        Put the sickle to the corn Astea 2018-02-13 08:27
        
        Put the sickle to the corn Helmut 2018-02-13 12:45
        
        Put the sickle to the corn Relaxation 2018-02-13 10:37
        
        multiple units, lag-times Helmut 2018-02-13 13:31

The mysterious ρ within studies [General Sta­tis­tics]

Complete thread:

The mysterious ρ within studies [General Statistics]