Bioequivalence and Bioavailability Forum

The mysterious ρ [General Sta­tis­tics]

posted by Helmut  – Vienna, Austria, 2018-02-08 22:40 (2267 d 15:09 ago) – Posting: # 18382
Views: 15,699

Hi Louis,

❝ But no one knows, at least not me, to what number the correlation should be set in practice.

❝ The authors team of the R package PowerTOST is currently discussing that theme. May be we came out with some aid in the near future.

Current state of affairs about the mysterious ρ:

Runtime 0.78 seconds. 6176 subjects in 124 data sets of 98 2×2×2 studies (74 analytes).
Evaluated by: lm(log(PK) ~ sequence+subject+period+treatment, data=study)
              PE.AUC[study]  <- exp(summary(model.AUC)$coef["treatmentT", "Estimate"])
              PE.Cmax[study] <- exp(summary(model.Cmax)$coef["treatmentT", "Estimate"])
              model.rho <- lm(PE.Cmax ~ PE.AUC)
              rho       <- sqrt(summary(model.rho)$r.squared)
rho         : 0.6983

---

PS: No, I’m not underpowering my studies for C_max. Some were so old that they were powered for an acceptance range of 75–133% or even 70–143%.  Was too lazy to browse through the protocols…

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Power and type I adjustment for 222BE when several PK prams considered Louis52 2018-02-07 21:04 [General Sta­tis­tics] 
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-07 22:37
  • Power of two combined TOST d_labes 2018-02-08 14:12
    • The mysterious ρHelmut 2018-02-08 21:40
      • ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
        • ρ ρ ρ your boat Helmut 2018-02-09 19:20
      • ...and a bonus question ElMaestro 2018-02-09 11:32
        • ...and a bonus question Helmut 2018-02-09 19:43
          • If u see a BEar don't forget to R oaρ Astea 2018-02-09 20:47
            • package install failed d_labes 2018-02-11 13:23
      • The mysterious ρ -between or within studies d_labes 2018-02-11 15:57
        • The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
            • The mysterious ρ within studies Helmut 2018-02-11 22:44
              • The mysterious ρ within studies nobody 2018-02-12 09:08
        • The mysterious ρ -between or within studies Astea 2018-02-11 17:34
          • The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
          • The mysterious ρ within studies Helmut 2018-02-11 22:48
  • Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
    • Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
      • reminds me of something ElMaestro 2018-02-12 09:18
        • reminds me of something nobody 2018-02-12 09:38
          • Hammer to fall Astea 2018-02-12 18:37
            • Put the sickle to the corn Helmut 2018-02-13 01:37
              • Put the sickle to the corn Astea 2018-02-13 08:27
                • Put the sickle to the corn Helmut 2018-02-13 12:45
              • Put the sickle to the corn Relaxation 2018-02-13 10:37
                • multiple units, lag-times Helmut 2018-02-13 13:31