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RegisterPower and type I adjustment for 222BE when several PK prams considered [General Statistics]
Hi Louis,
There is no alpha adjustment.
You need to show BE for both, usually. Sometimes even AUC in several flavours.
AUC and Cmax are positively correlated. That's something you may wish to factor in for sample size. However, in practice this requires a model for the correlation itself (for which nothing generally can be said) and besides it actually works quite well if you just dimension it according to the worst-case metric which tends to be Cmax.
❝ Can anyone direct me towards a thread where it is discussed/presented how to deal with alpha adjustment and power in case of multiplicity (AUC and Cmax considered at the same time)? Both CO and Parallel designs.
There is no alpha adjustment.
You need to show BE for both, usually. Sometimes even AUC in several flavours.
AUC and Cmax are positively correlated. That's something you may wish to factor in for sample size. However, in practice this requires a model for the correlation itself (for which nothing generally can be said) and besides it actually works quite well if you just dimension it according to the worst-case metric which tends to be Cmax.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Power and type I adjustment for 222BE when several PK prams considered Louis52 2018-02-07 21:04 [General Statistics]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Power and type I adjustment for 222BE when several PK prams consideredElMaestro 2018-02-07 22:37
- Power of two combined TOST d_labes 2018-02-08 14:12
- The mysterious ρ Helmut 2018-02-08 21:40
- ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
- ρ ρ ρ your boat Helmut 2018-02-09 19:20
- ...and a bonus question ElMaestro 2018-02-09 11:32
- ...and a bonus question Helmut 2018-02-09 19:43
- If u see a BEar don't forget to R oaρ Astea 2018-02-09 20:47
- package install failed d_labes 2018-02-11 13:23
- If u see a BEar don't forget to R oaρ Astea 2018-02-09 20:47
- ...and a bonus question Helmut 2018-02-09 19:43
- The mysterious ρ -between or within studies d_labes 2018-02-11 15:57
- The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
- The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
- The mysterious ρ within studies Helmut 2018-02-11 22:44
- The mysterious ρ within studies nobody 2018-02-12 09:08
- The mysterious ρ within studies Helmut 2018-02-11 22:44
- The mysterious ρ -between or within studies d_labes 2018-02-11 19:21
- The mysterious ρ -between or within studies Astea 2018-02-11 17:34
- The mysterious ρ -between or within studies d_labes 2018-02-11 19:36
- The mysterious ρ within studies Helmut 2018-02-11 22:48
- The mysterious ρ -between or within studies Helmut 2018-02-11 17:31
- ρ ρ ρ your boat ElMaestro 2018-02-09 09:58
- The mysterious ρ Helmut 2018-02-08 21:40
- Power and type I adjustment for 222BE when several PK prams considered ElMaestro 2018-02-11 18:43
- Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
- reminds me of something ElMaestro 2018-02-12 09:18
- reminds me of something nobody 2018-02-12 09:38
- Hammer to fall Astea 2018-02-12 18:37
- Put the sickle to the corn Helmut 2018-02-13 01:37
- Put the sickle to the corn Astea 2018-02-13 08:27
- Put the sickle to the corn Helmut 2018-02-13 12:45
- Put the sickle to the corn Relaxation 2018-02-13 10:37
- multiple units, lag-times Helmut 2018-02-13 13:31
- Put the sickle to the corn Astea 2018-02-13 08:27
- Put the sickle to the corn Helmut 2018-02-13 01:37
- Hammer to fall Astea 2018-02-12 18:37
- reminds me of something nobody 2018-02-12 09:38
- reminds me of something ElMaestro 2018-02-12 09:18
- Power and type I adjustment for 222BE when several PK prams considered nobody 2018-02-12 09:10
Ing. Helmut Schütz