Bioequivalence and Bioavailability Forum

Different PK profile [Study Assessment]

posted by ssussu – China, 2018-02-07 03:50 (2263 d 18:08 ago) – Posting: # 18365
Views: 9,423

Hi Helmut,

Thanks for your reply.

❝ Be aware that the dose will not be correct since likely you lost a part by flushing the tube. Whether this is really relevant depends on the lost volume / total infusion volume.

The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.

❝ 2. only if you lost nothing […] the C_max and AUC will equal the one with a constant rate infusion.

❝

❝ Example: t_½ 8 h, infusion interrupted after 15 min for 5 minutes, adjusted infusion rate, no dose lost.

❝

[image]

From the above picture, if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

When the the infusion speed deviate from the protocol specified ssussu 2018-02-06 10:48 [Study Assessment]
- Different PK profile Helmut 2018-02-06 13:28
  - Different PK profilessussu 2018-02-07 02:50
    - Different PK profile Helmut 2018-02-07 11:04
      - Different PK profile ssussu 2018-02-07 11:42
        
        Suitable equipment? Helmut 2018-02-07 14:13
        
        Suitable equipment? ssussu 2018-02-08 04:07
        
        AUC=f·D/CL Helmut 2018-02-08 10:28
        
        AUC=f·D/CL ssussu 2018-02-08 11:21
        
        AUC=f·D/CL Helmut 2018-02-08 21:55
        
        AUC=f·D/CL ssussu 2018-02-09 00:31
- When the the infusion speed deviate from the protocol specified ElMaestro 2018-02-07 13:20
  - When the the infusion speed deviate from the protocol specified ssussu 2018-02-08 04:23

Different PK profile [Study As­sess­ment]

Complete thread:

Different PK profile [Study Assessment]