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Hi Helmut,
Thank you for the explanation
Probably, most of the times we would actually know the PE from a previous study together with the CI. That's why I would not see the need the recalculate the PE (as the GMR for either AUCs or Cmaxs). But I completely agree that if we get from a published article only the information about the GMR limits for AUC or Cmax, then this is a very clever way of deriving the CVintra.
Couple of more questions:
Thank you for the explanation
Probably, most of the times we would actually know the PE from a previous study together with the CI. That's why I would not see the need the recalculate the PE (as the GMR for either AUCs or Cmaxs). But I completely agree that if we get from a published article only the information about the GMR limits for AUC or Cmax, then this is a very clever way of deriving the CVintra.
Couple of more questions:
- Presumably, n1 and n2 are form the previous study, right?
- Where 0.91 and 1.15 are coming from? Did you select them just as an example or there is a particular reason?
Complete thread:
- Finding the CI limits Louis52 2018-02-01 19:57 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CV from CI Helmut 2018-02-02 00:56
- CV from CI Louis52 2018-02-03 17:12
- CV from CI Helmut 2018-02-03 21:48
- CV from CILouis52 2018-02-04 14:38
- CV from CI Helmut 2018-02-05 11:39
- CV from CILouis52 2018-02-04 14:38
- CV from CI Helmut 2018-02-03 21:48
- CV from CI Louis52 2018-02-03 17:12
- CV from CI Helmut 2018-02-02 00:56
Ing. Helmut Schütz