Bioequivalence and Bioavailability Forum • Pooling is fooling?

Pooling is fooling? [🇷 for BE/BA]

posted by nobody – 2018-01-29 20:21 (2268 d 13:23 ago) – Posting: # 18304
Views: 13,108

Just some thoughts:

on one end of the pooling debate you can find meta-analysis. And their often far-reaching conclusions for "evidence-based medicine".
on the other end you find the headline of this post (without the question mark).

For me (considering the purpose of this thread) what is most appealing is:

reasonable worst-case scenario. Pick the studies comparable to yours and then make a worst-case assessment and base your numbers on this. Numbers considering the scientific (power) and economic (if necessary) considerations.

Then you have done much more than many before you. I see so so so often: "we choose to include 12 healthy volunteers". End of story. No rational, no numbers, no power, no nothing.

Study fails? How come? Big surprise..

—
Kindest regards, nobody

Complete thread:

Function CVpooled (package PowerTOST) Elena777 2018-01-21 08:53
- Function CVpooled (lengthy answer) Helmut 2018-01-21 17:21
  - Function CVpooled (lengthy answer) Elena777 2018-01-27 10:11
- Function CVpooled (package PowerTOST) ElMaestro 2018-01-27 22:28
  - Common sense Helmut 2018-01-28 00:27
    - Common sense ElMaestro 2018-01-28 08:43
      - Alzheimer’s Helmut 2018-01-28 11:38
  - To pool or not to pool d_labes 2018-01-28 13:52
- Function CVpooled (package PowerTOST) ElMaestro 2018-01-29 00:07
  - Pooling is fooling? Helmut 2018-01-29 17:53
    - Pooling is fooling?nobody 2018-01-29 19:21
      - Life is good ElMaestro 2018-01-30 18:23
        
        Life is good nobody 2018-01-30 18:31
        
        OT: Flags Helmut 2018-01-31 01:47
        
        OT: Flags nobody 2018-01-31 10:17
        
        OT: Flags ElMaestro 2018-01-31 11:02
        OT: Flags Helmut 2018-01-31 11:16
        
        OT: Flags nobody 2018-01-31 11:22
        
        OT: Flags Helmut 2018-01-31 11:38
        
        OT: Flags nobody 2018-01-31 12:28
        
        OT: Flags Helmut 2018-01-31 17:18
        
        OT: Flags nobody 2018-01-31 17:32
        
        OT: Flags Helmut 2018-01-31 19:00